Lions vs. Jaguars odds, line: 2020 NFL picks, Week 6 predictions from proven computer model

The Jacksonville Jaguars will take on the Detroit Lions at 1 p.m. ET on Sunday at TIAA Bank Field. Jacksonville is 1-4 overall and 1-1 at home, while Detroit is 1-3 overall and 1-1 on the road. The Jags close their practice facility on Saturday following a positive COVID-19 test for a practice squad player, but this game is expected to be held as scheduled. 

Detroit is favored by three points in the latest Jaguars vs. Lions odds from William Hill, and the over-under is set at 54.5. Before entering any Lions vs. Jaguars picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception five-plus years ago. It’s off to a strong 10-5 roll on top-rated picks this season. The model enters Week 6

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